Dr. Isaac Eliaz - Modified Citrus Pectin, Galectin-3, Long Covid and Chronic Fatigue.

Episode 67:

Modified Citrus Pectin, Galectin-3, Long Covid and Chronic Fatigue with Isaac Eliaz,

MD & Evan H. Hirsch, MD

Evan H. Hirsch, MD 00:08

Hey everybody, welcome back to the EnergyMD Podcast. So glad that you're here with

me today. Because, as you know, we look at all the causes of low energy and fatigue and

we're gonna be talking about detoxification as well as the survival protein with my new

friend Isaac Eliaz, and let's learn a little bit about him. So Dr. Isaac Eliaz is a leading

expert in the field of integrative medicine specializing in cancer, detoxification, immunity

and complex conditions. He is a respected physician, researcher, Best Selling Author,

educator, and mind body practitioner. Dr. Eliaz is partners with leading research

institutes including Harvard National Institute of Health, Columbia and others, to co

authored studies on integrative therapies for cancer, heavy metal toxicity and others. He

is founder and medical director of Amitabh ha medical clinic in Santa Rosa, California,

where he has pioneered the use of therapeutic apheresis as an adjunctive blood

filtration treatment for detox and chronic degenerative conditions. And we're going to

talk a little bit about its use in long COVID. So, Dr. Isaac, thank you so much for joining

me today.

Isaac Eliaz, MD 01:21

Thank you so much for having me and the opportunity to talk about such an important

topic.

Evan H. Hirsch, MD 01:29

So we're going to be talking about the survival paradox, toxins and the body's energy

systems. So you wrote the book, their survival paradox, can you tell us a little bit about

the book?

Isaac Eliaz, MD 01:41

Yes. So survivor paradox is really a combination of molteno for the for the 45 years of

studies, clinical experience, decades of meditation and research. And it really introduces

a new paradigm to an understanding of health and disease, you can say it's a paradigm

shift we are all aware of inflammation is a driving force for so many illnesses, so many

diseases, so many conditions. But inflammation is really not the cause inflammation is

really a result in what drives inflammation is the same thing that helps us survive. So

because we are built, we are wired to survive innately all the way to the cellular level, we

do it first by trying to develop as normal as possible embryonically. And as we come to

this world, and then by trying to repair any danger, any, any injury. And so because it's

automated in us, and it happened within fraction of a second within the autonomic

nervous system within the sympathetic system, by other fighting, which equates to

struggle to inflammation, or flight running away hiding, which, which equates with

isolation, with creating a micro environment where we can hide, which is the key factor

in energy related diseases in almost every disease, or by creating a shield, which, which

turns out into fibrosis and organ dysfunction. So while we have the sympathetic

response that can be balanced, if we take a deep breath, if we relax, if we breathe deep,

if we meditate, if we do something that gives us a sense of safety, the biochemistry

turns on through proteins called alarm rings, survival proteins, and one of the key ones

galectin. Three is the one that I've been researching for over 30 years. So while it turns

on in order to help us survive, it ends up driving inflammation, fibrosis, and it changes

the metabolic function of the cell. And as such, it will affect how the cell reacts with the

environment, how the cell will react intracellularly in the relationship between the cytosol

the cytoplasm of the cell and the mitochondria as the factory for energy. And that's

where we get to abnormal metabolic function and fatigue and burnout, etc. So it's all

that's why there is a Bible paradox. It's such a profound new aspect because you can

address it from the point of view of bio chemistry by blocking galectin Three, a lot of my

research was motivated respecting with over 80 published papers. You can address it,

with lifestyle, with nutrition with supplements, and you can understand it with a shift in

our state of mind state of how to move into a place of safety of open heart, instead of a

place of survival, of struggle, of a fight that burns us out. So this is really in a whole

model for how to live our life, but it's a very proof On effect on on our healing capacity.

Evan H. Hirsch, MD 05:04

So then, can we use galectin? Three as a marker for for disease or inflammation or

progress or response to treatment?

Isaac Eliaz, MD 05:16

Great question. I think I'm glad that you divided it into two parts. So So galectin Three is

definitely a general marker. Not only diagnostic, but prognostic. So, in general, in almost

every category of disease, if you look at the population, if it's autoimmune disease, if it's

cancers, if it's if it's cardiovascular disease, if it's narrow inflammation, that group with

higher level of galectin three will have a more severe disease and when you blog

electrons, we was modified to SPECT him, you will, you will attenuate you will, you will

attenuate the disease process and this is interesting when you look at it you have data

on on cancers, you have data on autoimmunity data on liver disease, heart disease,

kidney disease, lung disease, why? Because it's such a fundamental process, it doesn't

mean that you decide who you give modified with respecting to based on the level of

galectin three, because of certain genetic factors in metalloproteinase activities, certain

people will have lower level of galectin three because of the structure, Pinter, Mayo

Manomaya, but you still need to address it. However, for certain patients where you can

see that as they get worse, the galectin three goes up for any they get better than

Gilligans b goes down for this patient, it becomes a very an excellent biomarker. And the

last comment on this point, because it's important actually to comments is a person has

more explained than anyone in testing galectin. Three that standards for galectin. Three

in the labs. And by the way, testing a ligand three is approved by the FDA for almost for

about 13 years. It's done by every lab. It's inexpensive, inexpensive to do. And but the

standards are based on heart failure and patients with heart failure often have kidney

problems. And then malignancy goes up artificially. So it will say that normal is 17.8.

Also, this test was developed when it was manual. So now it's automated testing.

Anybody Above 1213 is already a concern, and should move to a full dose of of practice

all of 15 grams a day 14 Definitely. It's you don't see very often people have a 1617 in

heart failure specifically you do see. So this is a little bit about how how to really

understand the test. And when you block electing three, you don't necessarily remove it

but you block its detrimental effect. Because what he does is our survival power dogs

protein, when there's a problem, it goes to the area of the problem within minutes. And it

mobilizes different ligands inflammatory ligands hyperviscosity ligands, sticky molecule

like gains, immune modulating ligands in it and then they attach to each other and they

create Penta male and multiple pentamers Create a coating, great uglier lattice

formation that will constitute the arteriosclerotic plaque that will drive the biofilm, they

will read Dr. microenvironment for cancer we can can grow, that can write the place

where Lyme disease can hide in chronic you know, in different viruses, and, and, and,

and heavy metals and toxins etc. So when you disrupt the structure, you allow the body

to recalibrate, you allow the bodies to heal to heal. And it's interesting when I started my

journey with galectin, three and modified it respecting 2829 years ago, and I'm

collaborating with the people who started this with Dr. Avraham, Raj from Wayne State.

Nobody expected it to be such an active molecule for so many areas to the focus was

on cancer. But it's remarkable how much benefit it has blocking it because of its driving

force being an upstream protein. So the last comment on it because it's an upstream, if

you look at is a small change at the top is going to create a very big change over time.

So if you look at galectin three, between a normal person and and a patient with serious

condition, maybe it will double. You know, maybe it will go up by 50%. But when you look

at what it does to interleukin six, it will take it up 1004 A 5000 fold, because it's very

downstream. So when you blog, I've published a number of landmark papers showing

that in sepsis in animals, when we blog electron three, we completely attenuate the

interleukin six wise, we attenuate the kidney damage, and we attenuates the death in the

in the animals. And when a patient comes to the ICU with sepsis, with no pre existing

condition, like kidney disease, heart disease, or cancer, their level of galectin, through a

time of admission, will determine determine if they're going to die later on from the

sepsis. ICU. Same with COVID patients who come to the emergency room with COVID.

In the initial, very aggressive stage in 2020, very big study from Mexico City, regardless

of the involvement of the lungs level of galectin, three in the emergency room will

determine will determine who will make it to the ICU and who will actually die. Because

it's a very early, not only molecule, there is a process that is already starting. And by the

time we recognize it, because we haven't addressed the root cause, which is blocking

galectin. Three, or changing the survival response. It's kind of too late. It's like getting a

waterfall at the bottom with the bucket. It's not going to work.

Evan H. Hirsch, MD 11:23

So it seems like it's it's a really great marker to use. But it's not necessarily being used in

this way. So far, at least in it. I learned about it as a as a heart disease marker as a heart

failure marker. And that was in the integrative medicine community. So why do you think

that galectin Three is not being used more? Conventionally?

Isaac Eliaz, MD 11:47

No. The the famous saying that the Keith block showed its and his role for many years

ago. They said first, they ridicule you, then they fight you. And then they say it's self

evident. So now it's self evidence, I have a very large multi million dollar grant from the

NIH to study removal of galectin, three via phases in services. My second grant, you

know, I'm working with leading head of department is the most prestigious medical

centers in the world. It took only 30 years, you know, it's there. It's part of it is you have

to understand it, it has a complex role, and has huge interest in it. In fact, there is a

review article on on galectin Three galectin One also the different galaxies living through

this center, one, main one in cancer in in Asia review is like 112 Impact Factor, okay, I

didn't know that things exist, you know, huge review, talking how much it's how

important it is. And the first example of a block actually is, is my modified retrospective

with my studies. So it's kind of nice. So as you can see, I mean, it was in GNC or in

Journal of national national cancer institute in 9995. But you know, we know it, there is a

bias against natural products. And there is no big money to be made. I just presented a

poster session at ASCO, you know, the main cancer organism geo in San Francisco last

week, when an 18 month follow up on biochemical relapse of prostate cancer

supporting cancer was removed. There is no PSA, no prostate, no cancer. Now PSA

starts coming up. It's an indication of cancer. And the rise, the pace of rise is very

accurate determination of cancer progression. After 18 months multicenter for 60

patients that have whatever benefited after six months, moved on, most of them did, but

80% 90% of the patients had a slower progression, most of them stopping or both or

even going down. Compared to baseline 18 months ago, I had a poster session, if this

was a drug, I would have been in the plenary session, you know, and right and it would

have been in in in in New England Journal of Medicine. So I'm used to it. It even doesn't

frustrate it. It's part of my reality. It's the one part of the other pilot, I'm free and I'm not

bound, you know, by by more restrictions and being very much just, you know, science,

you know, very much just, you know, random, most clinical trial base, but it's part of the

bias. Now we have such amazing data that we're going to publish in the next year or two

about community results. At some point the dam is going to break you know, an

oncologist will start recommending modified respect in among a naturopath, for

example. It's the most recommended supplement in in nutrition and oncological support

by far. And it's not because of marketing, it's because of science and because of the

efficacy. So it just takes time and it does. Take a deep breath and you keep doing Your

work.

Evan H. Hirsch, MD 15:03

So let's talk about modified citrus pectin. Tell us about how it's constructed and the

things that it does in the body. So,

Isaac Eliaz, MD 15:13

citrus pectin is a long chain of carbohydrates of carbide with sugars, again, not sugar.

Glucose, is a very long chain, a very high molecular weight 100 to 300 kilo Dalton, it has

some branches, and it's highly esterified, it doesn't get absorbed into the bloodstream

from the gut, it's a good fiber, it can lower cholesterol can bind some toxins in the gut,

when you modify very specifically to a low molecular weight into a specific structure

using specific enzymes, it gets absorbed into the bloodstream, and there it has it

galectin Three blocking effect, in addition, modifies it respecting specifically vector soil

is very rich in in a in a compound called Ramnagar, electron and two, which is an

immune enhancing carbohydrate, it is also present in mistletoe, that's active one. And it

also has a very unique ability to bind to heavy metals. So it becomes a systemic,

systemic binder of heavy metals in addition to its other benefit, but what it does, it goes

and it blocks what we call the carbohydrate recognition domain, this this arm in the in

the galectin three is it binds to the different SD ligands and auto receptors, and it stops

the damaging effect. So when you look at the results, for example, in prostate cancer

have modified it to speckling. It is not because modifies it respecting kills cancer, it is

not because it modifies the hormonal receptors, which often, which is a main

mechanism of the basic drugs and also have some natural products. Because once you

change the hormonal expression of tumor, the clock starts ticking, the cancer will figure

it out, it literally allows the body to find the cancer better by changing the metabolic

environment by changing the micro environment by allowing oxygen to get into the into

into the tissue by attenuating, taking down the activity of the inflammatory macrophage

by regulating the cytokine excretion, and by regulating insulin receptors, so a NPK works

better into one gets blocked. Mitochondria functions better. And by up regulating p 53.

As a result of the cell can fight against cancer. And so as a result, one on one side effect

in these patients is that the memory gets better, the joint pains gets better, the energy

gets better, because the body is allowed to heal. And that's so that's what's so

fascinating about it.

Evan H. Hirsch, MD 18:03

Brilliant. And so this is all happening, because the modified SR pectin is acting on the

galectin three, or all those different mechanisms they were they were discussing, is it

acting on those in those different pathways? Or is there a central place that it's acting

where it's either binding up the the metals? Or it's blocking the galectin? Three? Or is it

just doing all these different things?

Isaac Eliaz, MD 18:31

So the binding of metals is a secondary benefit. Interesting. Yeah, how I got the idea, is

it the way we put from Chernobyl, in the very late 80s, early 90s. And children were

giving sodium pectate. And the radiation levels were because they were consuming it

with foods we got you really had to bite, you had to bind it in the gut. And there was like

a 60% reduction in radiation readings. No, the whole pectin industries thought My God,

he was a great market. And of course, nobody had the money to pay for the product.

And when I heard is that when I knew Wow. That's when it clicked for me that it's a

heavy metal key later. And then if since I modified it, it's going to be systemically I

remember I got the results of the study. I was just lecturing at 8pm which was a date

time, the prime organization you know, 23 years ago, and I just showed you, it wasn't the

PowerPoint that just put the slide on the screen and it showed the data. So that's

another benefit. The key benefit is the blocking of galectin three, because galectin three

drives the cytokine storm, it drives it, and galectin three drives interleukin six interleukin

one B interleukin four, TNF alpha, NF Kappa Beta, a TGF beta fibrotic pathway, they're all

starting with galectin three and that's why when we are blocking it and we get So maybe

I need downstream benefits, because it's really something that was going to help us.

And it never turned off. If we could turn it on for five minutes and turn it off, it would be

very important, it will still turn for five minutes. Because wherever it's needed, it will be

expressed. But it doesn't get blocked. And that's where the problem starts. And so it's

very exciting. I may, we have, we have data from very small animals, not only on the

blocking of EMS, on using MCP in attenuating sepsis, you know, 11 million people die

from sepsis. But also, when we remove a galectin, three in rats, they don't die from

sepsis. But now we're about to do the large animal studies. And if we show it, then we'll

move into clinical trial, but it's going to be a very elegant solution. If it works, I think it

will work, I just have to get into the stage to having the ICO interfere with this device that

can actually remove galectin Three, and basically take out the fire from the process

without depleting the patient without doing it's very elegant. We're just removing this,

this molecule that is in tiny amounts, they modified it to spec and the supplement does

something very similar. Of course, in sepsis, you need something very bombastic that

just depletes galectin Three in two hours, because otherwise the person will be dead.

But that's, that's part of the role of what he does.

Evan H. Hirsch, MD 21:37

And so then it sounds like you want the level to be less than 12 of the galectin three, and

so do you titrate up on the modified citrus pectin until you get there.

Isaac Eliaz, MD 21:48

Basically, the dosage or modified respecting, if you are very healthy, no no risk factor,

then maybe you're under 40 years old. And your galectin Three is under 10. You can take

five grams a day. And I can say comfortably not because I developed it. And you know,

20 years ago, it wasn't the first supplement I recommended. modified it to spec is the

most important supplement someone can take because it directly affects our longevity.

And but if you have any inflammation driven issues, if you want to detoxify, if you have

any risks. If you end if you're healthy, but you're collecting threes over 1112 You should

take 10 grams a day. If you have health concerns, you have to take 15 grams a day. If

you're collecting threes over 1718 You should take 20 grams. The only exception is

somebody who has advanced kidney failure advanced kidney failure is EGFR under

2530, then you will start with 10 V over 30 You can do 15 grams. The reason is, the

pickling is buffered with potassium and the kidney has a bit of a limited amount of

capacity to to excrete potassium. So if there's a little bit more careful in the same time,

there is very solid data that blocking galectin Three was modified to spec and improve

chronic kidney disease, which is my next topic, once I get done with sepsis is I'm a

strong believer based on clinical results, that chronic kidney disease is a treatable

condition that kidney function can be improved. You know, in, in medicine, we always

look at slowing down the deterioration but as long as the body is alive, as long as the

body is changing, the body has a choice which way it wants to go.

Evan H. Hirsch, MD 23:52

Interesting and so it sounds like you prefer the galectin three to be under 10

Isaac Eliaz, MD 23:58

Ideally, but it's depends on the the very curious cases or when somebody's like, is

healthy. And they come with a galectins we have 20 So either sometimes they have a lot

of heavy metals in in the bone marrow, like a lot of lead and some kind of dysfunction in

the bone marrow and inflammation in the which is stimulating galectin Three, they have

a scar either from surgery that didn't heal well. Or they have an internal scar or whatever

big emotional traumatic scar and they or they have some kind of disease they're not

aware of and yes and then and then then you need to give them a high dose and it

interesting using was in 15 grams because I came up with the 15 grams that now the

world is using and but some very smart patients. They figured out they were not getting

response at 15 at the time nobody could Measure galectin Three, and they just decided

to take 2025. And it worked. So it's simply that if you have more galectin, three or more

that you need to block, that's really why, why you need more as you get better. You can

Loida. And it's important to remember that galectin Three is our survival protein. But we

are not the only ones who want to survive. Our microbiome wants to live in harmony

with us. So when we disrupt our biofilm, it utilizes galectin, three to invade the lining of

the gut. The spike protein of the COVID of the Coronavirus is practically identical to the

lectin three. It's the same survivor protein of the virus in the place where there is the

highest amount of density of galectin, three receptors in the body is in the lungs.

Because the lungs is constant, from all the internal organs, the lungs are they wanted to

expose to the world right through air, they have no other first organ to be exposed to

take a deep breath, boom, it's in our lungs, we have to deal with it. So it's not surprising

that that we get this effect. But once for example, in COVID, the patient gets to be to

have kidney damage. Aki, then mortality skyrocketed, and it's driven by galectin. Three.

Evan H. Hirsch, MD 26:27

So then is the spike protein triggering the galectin three to increase? Or is it the spike

protein that then is causing similar type of inflammation as a lectin. Three,

Isaac Eliaz, MD 26:39

it's causing similar inflammation, there is data that blocking galectin Three helps

attenuate COVID data was already in in mid 2020. But I couldn't get a clinical trial

because it was so pharma based, you know, no hospital will will talk to me. But once it

create, it triggers in an inflammatory response. And once it gets to the kidneys, then the

galectins we excreted in the kidneys without putting the whole body into crisis. And

that's why it's so important to avoid Aki acute kidney injury, which is more common than

millions of cases a year. Crazy percentage of patients will get hospitalized. So in this

sense, you know, not only with COVID, with every infection, you have to address the

infectious agent, but it's usually the body's response that kills us, you know, right, as we

know, so well with COVID and with longhaul, COVID, and etc. So,

Evan H. Hirsch, MD 27:42

you know, right now and in society and in the world, we have this question of why are

some people getting long COVID and other people are not. And what I'm seeing is that a

lot of it has to do with the inflammation that's already built up in the people from things

like heavy metals, chemicals, molds, or other infections. I wonder if we can be using

galectin Three as a marker for those who would potentially get long COVID. Because

when you were talking about how some of these people who appear to be healthy,

because a lot of these people who are getting long, COVID are healthy, and they just go

back to training for their marathon too soon, that they probably have a galectin, three of

20. And these would be some of those people that we could check. And we could and

we could coach them differently on hey, you need to be extra careful if you get COVID

out or you know, because a lot of these people also with potentially progress to MECFS

chronic fatigue syndrome, right? Because they've got a number of these things they've

got they already have the inflammation that's present, and they just need something

that's the straw that breaks the camel's back. Does that make sense to you?

Isaac Eliaz, MD 28:49

I can't tell you how accurate you are. And the most important sentence you said

something, somebody who goes to marathon too soon. And that's a classical one. So all

of this is true people have high toxic burden, even when you can see people who have

like mold exposure, getting neurological diseases of the 20s like myasthenia gravis in

the 70s. I mean, it's insane unheard of. But when we utilize our immune system too

soon, we don't rest enough. Yeah, we may be okay but we are not able to repair properly

and the immune system will respond that what happened to me on a personal level. I

happen to be in Israel after two and a half years of not being there when I was about to

teach meditation healing between 250 people that were in the hallway. In 45 minutes

before the retreat, I do a COVID test and I'm positive one two, and I really was sick. If I

was at home I would have my sapling my IV that would take a complete rest for two

weeks. But here I am and I felt better about it. So I rested. But on day number three I was

negative within 48 hours. I started teaching far away from people then so He taught for

seven days, 150 people, it was amazing, my mind was trained enough to hold it. But

when I came back United States, my whole immune system and figured Lyme disease

when I was younger, it all exploded on me, you know. And then I recovered by letting go.

And then again, I worked, I went back in, I did my marathon of work too early. And then I

almost left this world. And now Now I'm fine. And now I know, I need to pace myself.

And so that's what happens very often. Past infections are really key Kiki, no peep,

people who really had had past infections, that's they will get triggered. It's a real issue.

So Lyme disease and inspire arcade, you know, weird viral illnesses, you know, of course,

all the you know, epstein barr, everything gets retriggered. And the really way to

understand it into into addresses is not to treat the disease to treat the person, if you

treat the person properly, the person will get better. And it's very universal for for any

chronic condition, because we, as human beings have the capacity to heal, we need to

connect with it, when it's an acute condition, it's a very different story, then you really hit

the pathogen as hard as you can cluding in Lyme disease, but once it becomes a

chronic condition, then every time we take aggressive measures, both the infectious

agent and both the body's response system will respond in a way that will will give us a

higher price, you know, later on. And but but the toxins are really key to what they do in

the future. You know, the famous thing in Hebrew, a vata glucosyl Vichy named Ben into

Cana, our ancestor ate unripe fruit, and we our teeth color will change. And that's an

example you know, and so that's, that's the power when we take care of our health, with

the ability to heal ourselves and to heal people around us, you know. And so all of these

pandemics, epidemics are giving us a real challenge, you know, really run for our money.

Evan H. Hirsch, MD 32:23

So you mentioned treating the person and not necessarily treating the disease or

treating the infection when we're talking about something chronic. Can you elaborate

more on that? It sounds like you're talking about mind body spirit, in addition to the

physical, but can you clarify?

Isaac Eliaz, MD 32:41

Yeah, and I would, I would qualify, the most dramatic, beneficial category of diseases is

fibromyalgia, chronic fatigue. It's incredible. So in my background, and I've started my

meditation training when I was 15, and 63. Now, and for 20 years, I would go to the

mountains for two months a year to meditate. And for 10 years, I did a half day retreat, if

they work, and I was fortunate to treat and study one on one with the greatest

meditation masters in the Himalayas. So I come with decades of training. So in a little

bit of gravity to my experience. And so the mind has an has the power to shift our ability

to heal. And from the perspective of the survivor paradox, it shifts us from a survival,

reactive response to an open heart love and compassion, responsiveness. Now this, we

can talk about it, from the point of view of what happened in the process of detox of

healing, we can talk about it from this term, that may sound a little esoteric, but I always,

I always give the examples all the way to cell function all the way to pathways. And

every cell in our body is built to survive. In the search. Every cell in our body wants to

take in nourishment, and throws out what he doesn't want in every citizen identified

entity with a boundary, a membrane, and he decides what comes in what comes out

through different receptors, different doors. And so we have this cell that kind of selfish,

they want to really get what they want, but they recognize that they are part of a

community of 50 trillion sales, rounding up a little bit, and it says, I didn't know it, and in

a few years, when I checked it, they go, it says, Have you normally we actually sell us

every second. 1 million reactions can you believe so even Can you imagine having like

50 trillion times 1 million a second, isn't it a miracle that we can talk forget about Talking

to languages, you know, that's completely mind blowing. Right? So we have this what we

call again, in Judaism called our footer, the date, you know, we support each other, right?

But it's a good deal. Now, it's only the Dalai Lama says to be selfless is a very good

thing. From a selfish point of view, you know, it helps us it helps our health. So but every

every organ takes care of itself and throws away what it wants. And if something

attacks the cell, it puts a fight, it changes the receptor that changes the environment, the

only organ that behaves differently is the heart. The heart is the only organ that not only

accept, but thrives on taking all the dirty blood from everybody, everything that the other

organ didn't want, that comes to the heart, that takes it with an open heart, otherwise,

the heart is not functioning, it connects with the universe with the breath. And then you

have the change of energy of oxygen in the lungs, which serves the heart. And then the

hearts give blood without discrimination, right, the altar is a stiff artery. But once the out,

the heart gives blood it relaxes, and who does it nourish the closer to the heart, it

nourishes itself, through the coronary arteries. So you know, it's part of nourishing itself,

in order to nourish others, and as part of nourishing others. So when we make this shift,

there is a cellular shift, suddenly, the cell relaxes. And then suddenly, pains go away. So

if we look at it from a spiritual point of view, and we take the esoteric into our body, the

heart just wants to give the heart you know, in almost every tradition, the connection

with the Divine happens in the heart. You know, in Buddhism, the Kooning God every

place, you know, it doesn't matter which which tradition, and then the heart just

connects with the universe and keeps, but and it gets through the blood. So the quality

of the blood is very, very important, how pure it is, how clean it is, how good is a

information that comes, but the sales have to be willing to receive, to open their arms to

open their heart. So when the silliness survival mode is you know, so Well, it goes into a

survival mode, it changes, the pH changes, the receptors, the macrophage become

inflammatory cytokines are not working well, in the cell is not functioning well, causing

mitochondrial dysfunction and chronic fatigue, diabetes, autoimmunity, or even if there

is oxygen, they won't function normally, because they're in a fighting mode. There's the

Warburg effect in cancer. So in chronic fatigue in every disease, if we can, we can let the

cells open up and connect with our heart healing will happen right away. And that's part

of what I teach. I teach the last decade mainly in Israel, but I'm going to start teaching in

other places. It's I call it open heart medicine, the infinite healing power of love and

compassion, and when so the way I teach it, that when people do this together with diet

and with exercise, it's profound, what can happen in a few days, you know, cancer

markers would get better. But chronic fatigue is one condition, when people suddenly

feel wow, I get my energy back. And so it's a great, it's definitely so that's the main part.

But of course, it has to be helped with supplement with nutrition with lifestyle. And

sometimes when you need more heroic measures, like therapeutic apheresis, then you

use more heroic measures, that's each person needs a different, different support level.

Evan H. Hirsch, MD 38:52

So the open heart medicine you were just describing is that mainly a meditation

practice. You talked about a number of other things along with it, but it sounded like

heart centered meditation.

Isaac Eliaz, MD 39:05

Yeah, but it's very, it's very sophisticated and very in simple in the same time, it's a

certain, with a certain development of a very common heart centered meditation called

tonglen. Exchanging suffering with love and compassion, which is done with outside

world. So I had this insight that I kept for myself for many, many years when I was in the

mountains for many months, about how to do it inside the body, all the way to the

cellular level. So now I teach it. And ideally, I teach it in a retreat environment because

the peeling of traumas of what we hold in our is so profound, but it's time for me to kind

of getting all time ready to just share it more widely actually wrote a book about it in

Hebrew it was supposed to come out just after is a COVID started so I put it on hold. I

will write it in English. It's my second book. Supposed to be my first somebody very, it's

very, very, it's really, it's something all of us can do every moment the issue even when

we meditate, we meditate outside. And we often skip the body. And the idea is to realize

that our inner space between our inner heart and our skin is infinite. Because every cell

in our body is our DNA, which is made out of infinite number of people, you think about

it, 25 years for generation, you go back 2000 years, it's an infinite number, you know, two,

two, to the 80s, an infinite number. And without doubt, and so you have the genetics.

And you have epigenetics. And there was one of the, one of the most sentences of

wisdom, ancient sentences in Hebrew says her called Sufi Valley shooting the tuna.

Everything is predetermined, that's genetics, that are shooting tuna, we have the choice

that epigenetics and it's so amazing how they knew this 1000s of years ago. So we in

our work in your work in my work, we are focused on the reshoot need to now on the our

ability to change our health. And in many levels, the more solid materialistic easy to feel,

touch, see, methods are easier to do, or easy work really easily how to, to keep, for

example, keeping a good diet, I mean, if we all kept a good diet, we would all feel much

better, you know, and an example. And the more you go to the subtle level, it gets a little

bit more complicated to connect. But once you make the change, there, you are making

the change in the source, and then it just washes into all the layers. So the idea is to try

to integrate. So in my personal journey, I was fortunate, you know, to start research on

this protein that nobody thought is so big about survival power dogs and find the

compounds that does it to therapeutic authorities, where I filter the blood outside the

body, right, bigger than the body in the same time to get this esoteric, meditation

training, or mostly acupuncture is so it was my my crazy journey, we all each have their

own crazy journey, right? But it's very tricky, especially with energy issues. Because

often, issues like fatigue, in pain are jeopardizing our life because there is a certain

pattern that has been established, I'm sure you know this well. And there is almost an

expectation when when symptoms start and we hit and usually, symptom number one is

followed by symptom number two and three, we make an assumption that if symptom

one appeared, now symptom two and symptom three are going to appear. And there's a

good reason to is they are the habits, they are the number illogical pathways that have

been established. So in order to heal, we need to wipe out the neurological pathways. So

meditation when very sophisticated, that's really open heart medicine, when we release

from the sale, does it and other healing methods do it? You know, there's a lot of interest

now in psychedelics for a very similar reason. And, yeah, if you can do it with

meditations, then you don't need to use other substances, but it takes a lot of training.

But it's the downside, the upside is that you can do it whenever you want. It's not you

don't know risks. And but really, it's very important for us, for anyone who has chronic

fatigue or somebody with severe Rickettsial disease and 88. And never bothered once

they get healed. I never bother to check even if I also had Lyme. And it took me years to

heal and but it didn't affect my life is really this anticipation that if I feel step number

one, step number two is going to happen. And then we restrict our life. We restrict what

we do. And then we fall into this pitfall. And the other part that is really important, again,

little bit deviating people who have issue with energy and pain, is that our repair our

recuperation is longer. For this patient, it takes longer to recuperate. So you have to time

yourself one of the biggest mistakes of people with with with fibromyalgia, chronic

fatigue, is it the over exert energy when they feel good. And they're not able to replenish

their reservoirs fast enough because mitochondria is not working with them because

they're clearing detox methods. It's not coming in. And that's really what you mentioned,

when you said that long haul is affected by infections and toxins and mold, all of these

disrupt our ability to detoxify, no, I'm kind of loading a lot and you just have to kind of

listen. But the toxins is big, you know, I, I overlooked, I overlooked I knew it, but I didn't, I

kind of accepted that, for example, we can all be bombarded with glyphosate. And it's

kind of the reality, right? Basically, everybody in that Estates is poisoned by a pesticide,

at one level or another everyone, literally 100%, you will find something in the urine, we

just got trained, it's acceptable to have a little bit of toxic of toxic material. And now I'm

doing research on how to remove it, I can see the effect on airway inflammation. And

you know, and cognitive function, again, very, very works very well, when you block a

galectin. Three with motivated respect in and you I have a certain formulation that for

this. And we're in the middle of our trials, you know, the first cases were amazing. But

we want to have like 2030 cases, and we'll have a big paper. One of the principles, at

least for me, I don't talk about a problem unless I can offer a solution. Because what's

the point right to just get people more anxious. And so it's an amazing journey to kind of

integrate these different things.

Evan H. Hirsch, MD 46:31

Well, I so appreciate you taking the time to share with us today. Such a wealth of

knowledge, I have two questions for you. And then we will conclude. So the first one is

when to take modified citrus pectin, because I've heard that you can take it with food

and with other supplements. But as a binder, I would imagine that it might bind those

things up. And so we may want to take it on an empty stomach. So I'm curious about

your opinion on that.

Isaac Eliaz, MD 46:58

Right. But remember, it also gets absorbed. So actually, I'm the guy who got started this

whole thing about doing it very far away from food, 15 minutes before food in a few

minutes before supplement, it's fine. It's not a problem, it doesn't have any effect on on.

On other things. It's nice, don't do it with food. But it's more important to do it, then to

skip it because you're not the right time. And you can do it only twice a day, there's no

need to do it three times a day is the half life, at least based on some studies we've

done is about 1012 hours. So it's pretty long. So towards so twice a day is fine.

Evan H. Hirsch, MD 47:37

And within this, so if you're doing a twice a day, the dosing that you were recommending

before five grams, 10 grams, 15 grams, is that total for the day? Or is that per dose,

Isaac Eliaz, MD 47:46

both total for the day. So 15 will be like one and a half scopes of practice or twice a day.

And then if you need 10, it's only one scoop or six capsules, I take capsules. And then if

you need more, yeah, you just divide the total amount.

Evan H. Hirsch, MD 48:03

Definitely. Excellent. Well, I still appreciate the clinical pearls, I'm definitely going to start

using galectin Three and more modified citrus pectin, I kind of moved away from it in

lieu of, of other binders and other things that I was using to remove toxins. But I just

love this able this ability to track the galectin three and kind of as an inflammatory

marker to kind of monitor some of the Freie fibrinolytic, not fibrinolytic, but the fibrin

producing changes and some of the other consequences of inflammation. So thank you

so much for that. And

Isaac Eliaz, MD 48:36

with other binders, it's not a problem. But it's more than a binder. It's common, it's really

it is also a binder, but it's much more than a binder.

Evan H. Hirsch, MD 48:47

So tell us about the best way for people to get access to you. We have a website here

Dr. Allah's dot org.

Isaac Eliaz, MD 48:53

Yeah, that's a good place the rls.org I have a research team that puts out a high quality

newsletter once a week. And they can find more information about my work, my

formulations, my my lectures, and I do hope it the second half of the year to offer a free

on Zoom retreat for a few days so people can experience the power of open heart

medicine and what it can do for them.

Evan H. Hirsch, MD 49:20

Definitely let me know about that because I'd like to share that with my audience and

probably attend myself as well. And then you also have a free chapter one in two of your

book survival paradox. So we'll go ahead and we'll put that link with this episode as well.

Wonderful, thank you so much for joining me today. It was a pleasure learning from you

and getting to know you better.

Isaac Eliaz, MD 49:47

Yeah, thank you for having me.

Evan H. Hirsch, MD 49:51

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